Todd Pezzi, MD, MBA
Board-Certified Radiation Oncologist
Todd Pezzi, MD first became interested in oncology at a young age after seeing cancer impact his own family. He is passionate about delivering state-of-the-art oncologic care to the residents of Southwest Florida.
A Philadelphia native, Dr. Pezzi attended Pennsylvania State University, where he earned his bachelor’s degree with high distinction. In 2017, Dr. Pezzi obtained his doctorate degree with honors from Baylor College of Medicine in Houston, Texas, and was elected to the Alpha Omega Alpha Honor Society. Additionally, he obtained his MBA from the Rice Jones Graduate School of Business and completed one year of residency in internal medicine.
Dr. Pezzi also completed a four-year residency program at the nation’s largest radiation oncology department: University of Texas MD Anderson Cancer Center in Houston, Texas. During this time, he has published nearly 40 peer-reviewed manuscripts in prestigious journals such as JAMA Oncology and Lancet Oncology. He also served as the primary investigator for a prospective clinical trial investigating a novel indication of stereotactic radiation therapy.
At Advocate Radiation Oncology, Dr. Pezzi treats patients for a variety of cancers including breast, prostate, lung, head and neck, skin, gastrointestinal, lymphoma, brain, sarcoma and also various benign diseases. All patients receive an individualized treatment plan based upon his experience using the most modern radiation techniques and advanced technology, including IMRT/VMAT, SBRT, IGRT, and brachytherapy.
Outside of the clinic, he enjoys spending time with his wife, Ashley. Together, they are raising their daughters, Sloane and Harper, as well as their two dogs. Dr. Pezzi loves to travel, explore local restaurants, watch the Philadelphia Eagles, and work on old cars.
Board Certification: American Board of Radiology
“I believe in treating every patient with the same empathy and respect I would want for my own family. It's not just about diagnosing and treating the disease—it's about understanding the patient, listening deeply, and offering support through every stage of treatment.”
Experience and education:
2023–Present: Southwest Florida Proton – Estero, FL
Board-Certified Radiation Oncologist
2022–Present: Advocate Radiation Oncology (ARO) – Naples, FL
Board-Certified Radiation Oncologist
2018–2022: MD Anderson Cancer Center (MDACC) – Houston, TX
Radiation Oncology Residency Training Program – Resident Physician, PGY5
2017–2018: Lankenau Medical Center (LMC) – Philadelphia, PA
Internal Medicine (Preliminary) Residency Training Program (PGY1)
2012–2017: Baylor College of Medicine (BCM) – Houston, TX
Doctor of Medicine (MD); Graduation with Honors & Alpha Omega
Alpha Honor Society
2014–2016: Rice University, Jones Graduate School of Business (JGSB) – Houston, TX; MBA, Full-Time Program, Healthcare Concentration
2008–2012: Pennsylvania State University, Eberly College of Science (PSU) – State College, PA, B.S. in Pre-Medicine; High Distinction & Phi Beta Kappa Honor Society
Reviews

was very positive and he is helping me in other matters.
I would recommend him to family and friends.
Extremely Kind
Extremely success in his practice
Extremely Helpful in rehab
He is “The Best”
He saved my wife from a stage IV Vaginal cancer and now me with a stage II prostate cancer. wouldn’t recommend anyone else
And thank you Emilee for everything and teaching me about self advocating and how important it is as a patient. You Rock!!!
And thank you to the team: Angie, Gerry, Hannah, Katelin, Patty, Connie, Christina, Evelyn and Quiomi. You all were awesome! *extra shout to Angie & Gerry, your kindness and heart and love thru my rough times mean more than you can ever know. Thank you!
Dr Nakfoor was amazing. So knowledgeable about my condition and consulted with another specialist while I was there to decide best course of treatment. Even followed up with me over the weekend.
Radiation Oncologist and Medical Director: 21st Century Oncology, Collier County

































































